John and Yul
A survivor of lung cancer in 1964, John Wayne went on to record a series of spots in the next decade for the American Cancer Society... Yul Brynner went him one better though, with an anti-smoking spot that ran posthumously:
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Talk about hedging your bets...
An atheist-sponsored ad campaign that started running on British buses last fall: "Probably?" "Probably?" That bit of uncertainty kind of undercuts the message, doesn't it? If you disagree, (re)consider these famous ad campaigns: